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Early Pregnancy Loss

MedGen UID:
823110
•Concept ID:
C3830362
•
Finding
Synonyms: Early Pregnancy Losses; Loss, Early Pregnancy; Losses, Early Pregnancy; Pregnancy Loss, Early; Pregnancy Losses, Early

Definition

Pregnancy loss before 10th week of gestation with documentation of a confirmed pregnancy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEarly Pregnancy Loss

Professional guidelines

PubMed

Management of Early Pregnancy Loss.
Neill S
JAMA 2023 Apr 25;329(16):1399-1400. doi: 10.1001/jama.2023.0933. PMID: 37027174
First Trimester Bleeding: Evaluation and Management.
Hendriks E, MacNaughton H, MacKenzie MC
Am Fam Physician 2019 Feb 1;99(3):166-174. PMID: 30702252
ACOG Practice Bulletin No. 200: Early Pregnancy Loss.
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2018 Nov;132(5):e197-e207. doi: 10.1097/AOG.0000000000002899. PMID: 30157093

Recent clinical studies

Etiology

Effects of preconception weight loss after lifestyle intervention on fertility outcomes and pregnancy complications.
Hoek A, Wang Z, van Oers AM, Groen H, Cantineau AEP
Fertil Steril 2022 Sep;118(3):456-462. doi: 10.1016/j.fertnstert.2022.07.020. PMID: 36116799
Antiphospholipid syndrome.
Sammaritano LR
Best Pract Res Clin Rheumatol 2020 Feb;34(1):101463. Epub 2019 Dec 19 doi: 10.1016/j.berh.2019.101463. PMID: 31866276
Ultrasound in Early Pregnancy: Viability, Unknown Locations, and Ectopic Pregnancies.
Scibetta EW, Han CS
Obstet Gynecol Clin North Am 2019 Dec;46(4):783-795. doi: 10.1016/j.ogc.2019.07.013. PMID: 31677754
First Trimester Bleeding: Evaluation and Management.
Hendriks E, MacNaughton H, MacKenzie MC
Am Fam Physician 2019 Feb 1;99(3):166-174. PMID: 30702252
The psychological impact of early pregnancy loss.
Farren J, Mitchell-Jones N, Verbakel JY, Timmerman D, Jalmbrant M, Bourne T
Hum Reprod Update 2018 Nov 1;24(6):731-749. doi: 10.1093/humupd/dmy025. PMID: 30204882

Diagnosis

Endometrial causes of recurrent pregnancy losses: endometriosis, adenomyosis, and chronic endometritis.
Pirtea P, Cicinelli E, De Nola R, de Ziegler D, Ayoubi JM
Fertil Steril 2021 Mar;115(3):546-560. Epub 2021 Feb 11 doi: 10.1016/j.fertnstert.2020.12.010. PMID: 33581856
Recurrent pregnancy loss.
Dimitriadis E, Menkhorst E, Saito S, Kutteh WH, Brosens JJ
Nat Rev Dis Primers 2020 Dec 10;6(1):98. doi: 10.1038/s41572-020-00228-z. PMID: 33303732
Antiphospholipid syndrome.
Sammaritano LR
Best Pract Res Clin Rheumatol 2020 Feb;34(1):101463. Epub 2019 Dec 19 doi: 10.1016/j.berh.2019.101463. PMID: 31866276
First Trimester Bleeding: Evaluation and Management.
Hendriks E, MacNaughton H, MacKenzie MC
Am Fam Physician 2019 Feb 1;99(3):166-174. PMID: 30702252
ACOG Practice Bulletin No. 200: Early Pregnancy Loss.
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2018 Nov;132(5):e197-e207. doi: 10.1097/AOG.0000000000002899. PMID: 30157093

Therapy

Effects of preconception weight loss after lifestyle intervention on fertility outcomes and pregnancy complications.
Hoek A, Wang Z, van Oers AM, Groen H, Cantineau AEP
Fertil Steril 2022 Sep;118(3):456-462. doi: 10.1016/j.fertnstert.2022.07.020. PMID: 36116799
Biologics for Inflammatory Bowel Disease and Their Safety in Pregnancy: A Systematic Review and Meta-analysis.
Nielsen OH, Gubatan JM, Juhl CB, Streett SE, Maxwell C
Clin Gastroenterol Hepatol 2022 Jan;20(1):74-87.e3. Epub 2020 Sep 12 doi: 10.1016/j.cgh.2020.09.021. PMID: 32931960
Medication to Manage Abortion and Miscarriage.
Beaman J, Prifti C, Schwarz EB, Sobota M
J Gen Intern Med 2020 Aug;35(8):2398-2405. Epub 2020 May 14 doi: 10.1007/s11606-020-05836-9. PMID: 32410127Free PMC Article
ACOG Practice Bulletin No. 200: Early Pregnancy Loss.
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2018 Nov;132(5):e197-e207. doi: 10.1097/AOG.0000000000002899. PMID: 30157093
Mifepristone Pretreatment for the Medical Management of Early Pregnancy Loss.
Schreiber CA, Creinin MD, Atrio J, Sonalkar S, Ratcliffe SJ, Barnhart KT
N Engl J Med 2018 Jun 7;378(23):2161-2170. doi: 10.1056/NEJMoa1715726. PMID: 29874535Free PMC Article

Prognosis

Single-cell DNA sequencing reveals a high incidence of chromosomal abnormalities in human blastocysts.
Chavli EA, Klaasen SJ, Van Opstal D, Laven JS, Kops GJ, Baart EB
J Clin Invest 2024 Jan 4;134(6) doi: 10.1172/JCI174483. PMID: 38175717Free PMC Article
The functional roles of protein glycosylation in human maternal-fetal crosstalk.
Zhong J, Li J, Burton GJ, Koistinen H, Cheung KW, Ng EHY, Yao Y, Yeung WSB, Lee CL, Chiu PCN
Hum Reprod Update 2024 Jan 3;30(1):81-108. doi: 10.1093/humupd/dmad024. PMID: 37699855
Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss.
Quenby S, Gallos ID, Dhillon-Smith RK, Podesek M, Stephenson MD, Fisher J, Brosens JJ, Brewin J, Ramhorst R, Lucas ES, McCoy RC, Anderson R, Daher S, Regan L, Al-Memar M, Bourne T, MacIntyre DA, Rai R, Christiansen OB, Sugiura-Ogasawara M, Odendaal J, Devall AJ, Bennett PR, Petrou S, Coomarasamy A
Lancet 2021 May 1;397(10285):1658-1667. Epub 2021 Apr 27 doi: 10.1016/S0140-6736(21)00682-6. PMID: 33915094
Recurrent pregnancy loss.
Dimitriadis E, Menkhorst E, Saito S, Kutteh WH, Brosens JJ
Nat Rev Dis Primers 2020 Dec 10;6(1):98. doi: 10.1038/s41572-020-00228-z. PMID: 33303732
Posttraumatic stress, anxiety and depression following miscarriage and ectopic pregnancy: a multicenter, prospective, cohort study.
Farren J, Jalmbrant M, Falconieri N, Mitchell-Jones N, Bobdiwala S, Al-Memar M, Tapp S, Van Calster B, Wynants L, Timmerman D, Bourne T
Am J Obstet Gynecol 2020 Apr;222(4):367.e1-367.e22. Epub 2019 Dec 13 doi: 10.1016/j.ajog.2019.10.102. PMID: 31953115

Clinical prediction guides

The endometrial microbiota and early pregnancy loss.
Odendaal J, Black N, Bennett PR, Brosens J, Quenby S, MacIntyre DA
Hum Reprod 2024 Apr 3;39(4):638-646. doi: 10.1093/humrep/dead274. PMID: 38195891Free PMC Article
The functional roles of protein glycosylation in human maternal-fetal crosstalk.
Zhong J, Li J, Burton GJ, Koistinen H, Cheung KW, Ng EHY, Yao Y, Yeung WSB, Lee CL, Chiu PCN
Hum Reprod Update 2024 Jan 3;30(1):81-108. doi: 10.1093/humupd/dmad024. PMID: 37699855
Effects of preconception weight loss after lifestyle intervention on fertility outcomes and pregnancy complications.
Hoek A, Wang Z, van Oers AM, Groen H, Cantineau AEP
Fertil Steril 2022 Sep;118(3):456-462. doi: 10.1016/j.fertnstert.2022.07.020. PMID: 36116799
Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss.
Quenby S, Gallos ID, Dhillon-Smith RK, Podesek M, Stephenson MD, Fisher J, Brosens JJ, Brewin J, Ramhorst R, Lucas ES, McCoy RC, Anderson R, Daher S, Regan L, Al-Memar M, Bourne T, MacIntyre DA, Rai R, Christiansen OB, Sugiura-Ogasawara M, Odendaal J, Devall AJ, Bennett PR, Petrou S, Coomarasamy A
Lancet 2021 May 1;397(10285):1658-1667. Epub 2021 Apr 27 doi: 10.1016/S0140-6736(21)00682-6. PMID: 33915094
Recurrent pregnancy loss.
Dimitriadis E, Menkhorst E, Saito S, Kutteh WH, Brosens JJ
Nat Rev Dis Primers 2020 Dec 10;6(1):98. doi: 10.1038/s41572-020-00228-z. PMID: 33303732

Recent systematic reviews

COVID-19 in pregnant women: a systematic review and meta-analysis on the risk and prevalence of pregnancy loss.
van Baar JAC, Kostova EB, Allotey J, Thangaratinam S, Zamora JR, Bonet M, Kim CR, Mofenson LM, Kunst H, Khalil A, van Leeuwen E, Keijzer J, Strikwerda M, Clark B, Verschuuren M, Coomarasamy A, Goddijn M, van Wely M; PregCOV-19 Living Systematic Review Consortium
Hum Reprod Update 2024 Mar 1;30(2):133-152. doi: 10.1093/humupd/dmad030. PMID: 38016805Free PMC Article
Obstetric and neonatal outcomes after natural versus artificial cycle frozen embryo transfer and the role of luteal phase support: a systematic review and meta-analysis.
Zaat TR, Kostova EB, Korsen P, Showell MG, Mol F, van Wely M
Hum Reprod Update 2023 Sep 5;29(5):634-654. doi: 10.1093/humupd/dmad011. PMID: 37172270Free PMC Article
Paternal Medications in Inflammatory Bowel Disease and Male Fertility and Reproductive Outcomes: A Systematic Review and Meta-analysis.
Gubatan J, Barber GE, Nielsen OH, Juhl CB, Maxwell C, Eisenberg ML, Streett SE
Clin Gastroenterol Hepatol 2023 Aug;21(9):2222-2238. Epub 2022 Jul 20 doi: 10.1016/j.cgh.2022.07.008. PMID: 35870769
Biologics for Inflammatory Bowel Disease and Their Safety in Pregnancy: A Systematic Review and Meta-analysis.
Nielsen OH, Gubatan JM, Juhl CB, Streett SE, Maxwell C
Clin Gastroenterol Hepatol 2022 Jan;20(1):74-87.e3. Epub 2020 Sep 12 doi: 10.1016/j.cgh.2020.09.021. PMID: 32931960
Advances in the management of early pregnancy loss.
Henkel A, Shaw KA
Curr Opin Obstet Gynecol 2018 Dec;30(6):419-424. doi: 10.1097/GCO.0000000000000501. PMID: 30299321

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